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Podocytes, a cell type playing a major role in glomerular filtration barrier integrity, has been shown to display ferroptosis activation upon high glucose exposure through the antioxidant molecule peroxiredoxin 6 (Prdx6) (65)

Cell 171(3):628-641.e26 Anthonymuthu TS et al (2018) Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE

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These carriers can be engineered for surface modification with ligands targeting dopaminergic neurons or inflamed brain regions, enabling precision delivery and minimizing off-target toxicity (Naqvi et al., 2020

The study was modified after randomization and treatment of 117 patients to require that all patients receive folic acid 350 mcg to 1,000 mcg daily beginning 1 to 3 weeks prior to the first dose of pemetrexed and continuing until 1 to 3 weeks after the last dose, vitamin B 12 1,000 mcg intramuscularly 1 to 3 weeks prior to first dose of pemetrexed and every 9 weeks thereafter, and dexamethasone 4 mg orally, twice daily, for 3 days starting the day prior to each pemetrexed dose

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